反应 #1596945

反应方程式

2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran

triethylamine

→

2-fluoro-4-(5-propyltetrahydropyran-2-yl)phenol

溶剂

MTBE

toluene water

反应条件

后处理

1. 1
   其他the organic phase is separated off
2. 2
   萃取The aqueous phase is extracted with MTBE
3. 3
   洗涤The combined organic phases are washed with water
4. 4
   其他dried
5. 5
   浓缩The solution is concentrated to dryness
6. 6
   其他the residue is used directly for the following reaction

实验过程

123.0 g (0.30 mol) of 2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran are hydrogenated in toluene/water in the presence of Pd/C (5% of Pd) and 86.0 ml (0.60 mol) of triethylamine. The reaction solution is diluted with MTBE, and the organic phase is separated off. The aqueous phase is extracted with MTBE. The combined organic phases are washed with water and dried using sodium sulfate. The solution is concentrated to dryness, and the residue is used directly for the following reaction.

来源