反应 #1596940

反应方程式

phenyl isothiocyanate

2-amino-2-methyl-1-propanol

→

N-(1-hydroxy-2-methylpropan-2-yl)-N′-phenylthiourea

收率 60.0%

溶剂

chloroform

chloroform

反应条件

后处理

1. 1
   workup.ADDITIONwas slowly added dropwise to the mixture over one hour
2. 2
   workup.ADDITIONUpon completion of the addition
3. 3
   workup.STIRRINGthe resulting mixture was stirred for 12 hours at room temperature
4. 4
   温度The precipitated crystals were refluxed
5. 5
   温度with heat
6. 6
   workup.DISSOLUTIONto be dissolved
7. 7
   其他recrystallized
8. 8
   其他The crystals thus obtained
9. 9
   过滤were collected by filtration
10. 10
    洗涤washed with 20 mL of diethyl ether three times
11. 11
    其他dried under reduced pressure at room temperature

实验过程

In 500 g of chloroform was dissolved 2-amino-2-methyl-1-propanol (61.6 g, 0.69 moL). Then, 300 g of chloroform solution containing phenyl isothiocyanate (81.6 g, 0.6 moL) was slowly added dropwise to the mixture over one hour, while stirring. Upon completion of the addition, the resulting mixture was stirred for 12 hours at room temperature. The precipitated crystals were refluxed with heat to be dissolved and then recrystallized. The crystals thus obtained were collected by filtration, washed with 20 mL of diethyl ether three times, and then dried under reduced pressure at room temperature to give 80.1 g of N-(1-hydroxy-2-methylpropan-2-yl)-N′-phenylthiourea (yield 60%).

来源