反应 #159280

反应方程式

Z-Gly-OH

THF

DIEA

TSTU

→

Z-Gly-OSu

收率 92.0%

溶剂

AcOEt

反应条件

后处理

1. 1
   洗涤the mixture was washed with 0.2N hydrochloric acid (100 ml) and water (2×100 ml)
2. 2
   干燥The organic phase was dried (Na2SO4)
3. 3
   浓缩concentrated in vacuo

实验过程

Z-Gly-OH (1.0 g, 4.78 mmol) was added THF (10 ml), DIEA (0.98 ml, 5.74 mmol), and TSTU (1.7 g, 5.74 mmol) and the resulting mixture was stirred at room temperature for 2 hours. AcOEt (100 ml) was added and the mixture was washed with 0.2N hydrochloric acid (100 ml) and water (2×100 ml). The organic phase was dried (Na2SO4) and concentrated in vacuo to afford 1.34 g (92%) of Z-Gly-OSu as an oil.

来源