反应 #1592785

反应方程式

phenylmethanesulfonyl chloride

(4-bromo-2-fluoro-phenyl)methanamine

N,N-diisopropylethylamine

→

N-[(4-bromo-2-fluoro-phenyl)methyl]-1-phenyl-methanesulfonamide

收率 80.1%

溶剂

dichloromethane

dichloromethane

反应条件

后处理

1. 1
   洗涤washed with water and brine
2. 2
   干燥dried with MgSO4
3. 3
   浓缩concentrated
4. 4
   其他purified by silica gel column chromatography (20-100% EtOAc in heptane)

实验过程

To a solution of (4-bromo-2-fluoro-phenyl)methanamine (3 g, 14.7 mmol) in dichloromethane (50 mL) was added N,N-diisopropylethylamine (3.3 mL, 19.1 mmol), followed by phenylmethanesulfonyl chloride (3.3 g, 17.6 mmol) and the reaction was stirred at ambient temperature for 3 hours. The reaction was diluted with dichloromethane and washed with water and brine, dried with MgSO4, concentrated and purified by silica gel column chromatography (20-100% EtOAc in heptane) to give N-[(4-bromo-2-fluoro-phenyl)methyl]-1-phenyl-methanesulfonamide (4.22 g, 80% yield). LCMS (m/z) ES+ 358 [M+1]+.

来源