反应 #159240

反应方程式

lithium bis-(trimethylsilylamide)

(−)-cephalotaxine

acetic anhydride

→

Lithium bis-(trimethylsilyl)amide

溶剂

tetrahydrofurane

tetrahydrofurane

butyllithium

反应条件

后处理

1. 1
   workup.ADDITIONthe reaction mixture was treated like method above-mentioned in 1°)
2. 2
   其他The product thus obtained

实验过程

A commercial solution of lithium bis-(trimethylsilylamide) 1M in tetrahydrofurane (0.95 ml, 0.95 mmol) was added to a stirred solution of (−)-cephalotaxine (200 mg, 0.63 mmol) in anhydrous tetrahydrofurane at −40° C. After stirring for 5 minutes, acetic anhydride (90 μl, 0.95 mmol) was added, and the reaction mixture was treated like method above-mentioned in 1°). The product thus obtained showed identical characteristics to this obtained above in butyllithium method.

来源