反应 #158418

反应方程式

HCl

NaOH

ethyl 3-(1-(3,4-difluorophenyl)cyclohexyl)propanoate

NaOH

→

3-(1-(3,4-difluorophenyl)cyclohexyl) propanoic acid

收率 100.0%

溶剂

MeOH

反应条件

后处理

1. 1
   workup.STIRRINGto stir for 3 hrs
2. 2
   萃取the product was extracted with EtOAc
3. 3
   洗涤The extract was washed with water and brine
4. 4
   干燥dried over Na2SO4
5. 5
   其他evaporated

实验过程

To a solution of ethyl 3-(1-(3,4-difluorophenyl)cyclohexyl)propanoate (540 mg, 1.822 mmol) in MeOH (15 mL) was added 1N NaOH (3.64 mL, 3.64 mmol), and the mixture was stirred at room temperature for 20 hrs. Since the reaction was not complete on TLC, an additional 1.82 mL of 1N NaOH was added, and it was continued to stir for 3 hrs. TLC showed that the reaction was complete. Next, the reaction mixture was acidified with the addition of 6 mL of 1N HCl, and the product was extracted with EtOAc. The extract was washed with water and brine, dried over Na2SO4, and evaporated to give 3-(1-(3,4-difluorophenyl)cyclohexyl) propanoic acid (489 mg, 1.822 mmol, 100% yield) as a white solid.

来源