反应 #158392

反应方程式

5-(4-bromo-2-methoxyphenyl)-2-methyl-1,3-oxazole

5-chloropent-1-yne

triethylamine

→

title compound

5-[4-(5-chloropent-1-yn-1-yl)-2-methoxyphenyl]-2-methyl-1,3-oxazole

溶剂

ethyl acetate

反应条件

后处理

1. 1
   过滤the mixture was filtered through celite
2. 2
   其他The solvent was evaporated under reduced pressure
3. 3
   其他the residue was purified by silica gel column chromatography (ethyl acetate/hexane)

实验过程

A mixture of 5-(4-bromo-2-methoxyphenyl)-2-methyl-1,3-oxazole (6.00 g), 5-chloropent-1-yne (4.74 mL), dichlorobis(triphenylphosphine)palladium(II) (1.57 g), copper(I) iodide (426 mg) and triethylamine (60 mL) was stirred at 70° C. for 3 hr, and diluted with ethyl acetate, and the mixture was filtered through celite. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (4.85 g).

来源