反应 #158342

反应方程式

sodium hydrogen carbonate

Ethyl 8-chloro-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate

3-(trifluoromethyl)phenol

potassium carbonate

→

title compound

收率 50.9%

ethyl 3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[3-(trifluoromethyl)phenoxy]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate

收率 50.9%

溶剂

DMF

反应条件

后处理

1. 1
   萃取the mixture was extracted with ethyl acetate
2. 2
   洗涤The extract was washed with saturated brine
3. 3
   干燥dried over anhydrous sodium sulfate
4. 4
   其他the solvent was evaporated under reduced pressure
5. 5
   其他The residue was purified by silica gel column chromatography (ethyl acetate/hexane)

实验过程

Ethyl 8-chloro-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate (1.0 g) was added to a mixture of 3-(trifluoromethyl)phenol (408 mg), potassium carbonate (995 mg) and DMF (10 mL) at 90° C., and the mixture was stirred for 30 min. Saturated aqueous sodium hydrogen carbonate solution was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (663 mg).

来源