反应 #158015

反应方程式

tert-butyl 4-(biphenyl-4-yl)-3-(tert-butoxycarbonylamino)butanoate

HCl

1,4-dioxane

→

3-amino-4-biphenyl-4-yl-butyric acid tert-butyl ester hydrochloride

反应条件

后处理

1. 1
   浓缩the reaction mixture is concentrated

实验过程

To tert-butyl 4-(biphenyl-4-yl)-3-(tert-butoxycarbonylamino)butanoate (110 mg, 0.267 mmol), a solution of 4 M HCl in 1,4-dioxane (0.668 ml, 2.67 mmol) is added. After stirring for 1 h, the reaction mixture is concentrated to give crude 3-amino-4-biphenyl-4-yl-butyric acid tert-butyl ester hydrochloride.

来源