反应 #157964

反应方程式

hydrochloric acid dioxane

tert-butyl 4-cyano-4-(hydroxymethyl)piperidine-1-carboxylate

→

4-(hydroxymethyl)piperidine-4-carbonitrile hydrochloride

溶剂

dioxane

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated under reduced pressure

实验过程

4 M hydrochloric acid/dioxane solution (15 ml) was added to a solution of tert-butyl 4-cyano-4-(hydroxymethyl)piperidine-1-carboxylate (886 mg) in dioxane (5 ml), and stirring was performed for one hour at room temperature. The reaction mixture was concentrated under reduced pressure, and 4-(hydroxymethyl)piperidine-4-carbonitrile hydrochloride (663 mg) was obtained.

来源