反应 #1575

反应方程式

4'-chloro-2'-fluoro-5'-nitroacetanilide

hydrogen

→

title product

5'-Amino-4'-chloro-2'-fluoroacetanilide

溶剂

ethanol tetrahydrofuran

反应条件

后处理

1. 1
   过滤The reaction mixture is then filtered
2. 2
   浓缩concentrated in vacuo

实验过程

A mixture of 4'-chloro-2'-fluoro-5'-nitroacetanilide (35.2 g, 151 mmol), and 5% platinum on carbon (7.0 g, 20 wt/wt %) in an ethanol/tetrahydrofuran (2:1) solution is hydrogenated until 28 psi of hydrogen is taken up. The reaction mixture is then filtered, and concentrated in vacuo to give the title product as a tan solid which is identified by 1H NMR spectral analysis.

来源