反应 #157154

反应方程式

4,6-dichloropyridin-2-amine

K2CO3

Et2Zn

→

4-chloro-6-ethylpyridin-2-amine

收率 33.0%

溶剂

THF

反应条件

后处理

1. 1
   温度Upon cooling to room temperature
2. 2
   萃取the mixture was extracted with EtOAc
3. 3
   干燥dried with Na2SO4
4. 4
   浓缩concentrated
5. 5
   其他The crude material was purified via SiO2 column chromatography
6. 6
   洗涤eluting with DCM/MeOH (2%)

实验过程

To a solution of 4,6-dichloropyridin-2-amine (1.0 equiv.) in THF (0.1M) was added Pd(dppf)Cl2-DCM (0.1M), K2CO3 (3.0 equiv.), and Et2Zn (1.2 equiv.). The reaction was heated to 70° C. for 18 hrs. Upon cooling to room temperature, NH4Cl(sat.) was added, the mixture was extracted with EtOAc, dried with Na2SO4, and concentrated. The crude material was purified via SiO2 column chromatography eluting with DCM/MeOH (2%) to yield 4-chloro-6-ethylpyridin-2-amine in 33% yield. LCMS (m/z): 157.1 (MH+).

来源