反应 #1569

反应方程式

2-aminoethanethiol

triethylamine

ethyl 2,3-di-bromopropionate

chloroform toluene

→

title product

Ethyl 3-thiomorpholinecarboxylate

溶剂

chloroform

反应条件

后处理

1. 1
   过滤filtered
2. 2
   浓缩concentrated in vacuo
3. 3
   其他to obtain an orange liquid
4. 4
   workup.DISTILLATIONdistilled

实验过程

A warm solution of 2-aminoethanethiol (10.0 g, 0.130 mol) and triethylamine (36 mL, 0.260 mol) in chloroform is added over 5 minutes to a solution of ethyl 2,3-di-bromopropionate (33.9 g, 0.130 mol) in a chloroform/toluene (1:1.6) solution. The reaction mixture is stirred at room temperature for 2.5 hours, filtered and concentrated in vacuo to obtain an orange liquid. The liquid is vacuum distilled to give the title product as a colorless liquid, bp 121°-124° C. at 3 mm Hg.

来源