反应 #1563934

反应方程式

NaBH4

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

→

title compound

收率 79.8%

2-(2,5-difluorophenyl)pyrrolidine

收率 79.8%

溶剂

MeOH H2O

反应条件

后处理

1. 1
   其他The reaction mixture was quenched with 1N aqueous HCl solution
2. 2
   萃取extracted with DCM
3. 3
   干燥dried over anhydrous sodium sulphate
4. 4
   浓缩concentrated under reduced pressure

实验过程

NaBH4 (12 g, 314.9 mmol) was added to a solution of 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (28.5 g, 157.4 mmol) in a mixture of MeOH:H2O (4:1, 250 mL) and stirring was continued at 25-35° C. for 2 h. The reaction mixture was quenched with 1N aqueous HCl solution and basified with 2N aqueous NaOH solution, extracted with DCM, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 23 g of the title compound.

来源