反应 #1563907

反应方程式

NaHCO3

3,4-(Methylenedioxy)aniline

Ac2O

→

N-(benzo[d][1,3]dioxol-5-yl)acetamide

收率 95.0%

溶剂

AcOH

反应条件

后处理

1. 1
   其他After reaction
2. 2
   过滤filtered
3. 3
   萃取The filtrate was extracted with ethyl acetate

实验过程

To a solution of 3,4-(Methylenedioxy)aniline (8 g, 58.3 mmol) in AcOH (120 ml) was added Ac2O (48 mL). The mixture was stirred for overnight. After reaction, the mixture was poured into saturated NaHCO3 solution, and then filtered. The filtrate was extracted with ethyl acetate to give N-(benzo[d][1,3]dioxol-5-yl)acetamide (10 g, 95%). LCMS: 180[M+1]+; 1H NMR (DMSO-d6) δ 2.0 (s, 3H), 5.96 (s, 2H), 6.82 (d, 1H, J=8.1 Hz), 6.91 (d, 1H, J=2.1 Hz), 7.30 (d, 1H, J=1.8 Hz), 9.84 (s, 1H).

来源