反应 #156301

反应方程式

tert-butyl 4-[(cyclopropyloxy)methyl]piperidine-1-carboxylate

trifluoroacetic acid

→

4-[(cyclopropyloxy)methyl]piperidine

收率 62.2%

溶剂

dichloromethane

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated under reduced pressure
2. 2
   workup.ADDITIONto the residue were added a saturated aqueous sodium hydrogen carbonate solution and ethyl acetate
3. 3
   其他the aqueous layer was separated
4. 4
   洗涤The organic layer was washed with saturated brine
5. 5
   干燥dried over anhydrous magnesium sulfate
6. 6
   其他the solvent was evaporated under reduced pressure
7. 7
   其他The residue was purified by basic silica gel column chromatography (chloroform/methanol)

实验过程

To a solution of 2.0 g of tert-butyl 4-[(cyclopropyloxy)methyl]piperidine-1-carboxylate in 20 mL of dichloromethane was added 3.0 mL of trifluoroacetic acid, followed by stirring at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, and to the residue were added a saturated aqueous sodium hydrogen carbonate solution and ethyl acetate, and then the aqueous layer was separated. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by basic silica gel column chromatography (chloroform/methanol) to obtain 756 mg of 4-[(cyclopropyloxy)methyl]piperidine.

来源