反应 #155319

反应方程式

5-Methylbenzofuran-7-ylamine

ethanol

→

5-methyl-2,3-dihydrobenzofuran-7-ylamine

收率 87.6%

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他followed by conduction of catalytic reduction at room temperature under ordinary pressure
2. 2
   其他The catalyst was removed by celite filtration
3. 3
   其他condensed under reduced pressure
4. 4
   干燥dried over anhydrous magnesium sulfate
5. 5
   浓缩concentrated to dryness under reduced pressure

实验过程

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

来源