反应 #1543069

反应方程式

NaOH

3

Ethyl 5-acetaminoindole-2-carboxylate

→

powder

收率 71.0%

5-Acetaminoindole-2-carboxylic acid

收率 71.0%

溶剂

methanol

反应条件

后处理

1. 1
   其他The reaction mixture was evaporated
2. 2
   workup.ADDITIONwater (5 mL) was added
3. 3
   过滤the precipitate was filtered
4. 4
   洗涤washed with water

实验过程

3N NaOH (2 mL) was added to a solution of 3 (250 mg, 1.02 mmol) in methanol (7 mL) and the reaction mixture was stirred overnight at room temperature. The reaction mixture was evaporated and water (5 mL) was added. The solution was neutralized to pH 2 using 20% HCl and the precipitate was filtered and washed with water. 4 was obtained as a grey powder (158 mg, 71% yield), mp: 260° C. (dec). 1H NMR (DMSO-d6, ppm): 11.62 (s, 1 H, NH), 9.77 (s, 1 H, NH), 7.98-7.97 (d, 1 H, J=1.4 Hz, Ar--H), 7.36-7.28 (m, 2 H, Ar--H), 7.02 (d, 1 H, J=1.5 Hz, Ar--H), 2.03 (s, 3 H, CH3CO), Anal. (C11H10N2O3 0.6H2O), C, H, N.

来源