反应 #1543059

ord-458c992ed9b1480189a6dcd8e8532f12

反应方程式

C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
Dehydroepiandrosterone
c1ccncc1
pyridine
O
water
→
CC(=O)O[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]32)C1
3β-acetoxy-5-androstene-17-one

反应物

C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
Dehydroepiandrosterone
c1ccncc1
pyridine
O
water

试剂

无

溶剂

—
anhydride acetic

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    过滤crystals are filtered
  2. 2
    其他dried in vacuo

实验过程

Dehydroepiandrosterone (2.88 g, 10 mmol) is dissolved in a mixture (100 ml) of anhydride acetic and pyridine (1:1 v/v) and left at room temperature for 16 h. The mixture is then poured carefully into iced water and after 16 h, crystals are filtered and dried in vacuo.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US05843932uspto-grants-1998_12