反应 #1543058

ord-a107ddf09ac14b8981d1d8f9172c521a

反应方程式

C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
dehydroepiandrosterone
O
water
O=CO
formic acid
→
C[C@]12CC[C@H](OC=O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
3β-formyloxy-5-androstene-17-one

反应物

C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
dehydroepiandrosterone
O
water
O=CO
formic acid

试剂

无

反应条件

温度
60°CELSIUS
详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    温度After cooling
  2. 2
    过滤crystals are filtered
  3. 3
    其他dried in vacuo

实验过程

Following the procedure described by Ringold (H. J. Ringold, et al., J. Am. Chem. Soc. 78, 816, 1956), dehydroepiandrosterone (2.88 g, 10 mmol) dissolved in 85% formic acid (100 mL) is heated at 60° C. for 1 h. After cooling, the mixture is poured into iced water and after 16 h, crystals are filtered and dried in vacuo.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US05843932uspto-grants-1998_12