反应 #1524

反应方程式

4-hydroxymethyl-4'-decyloxybiphenyl

HBr

→

4'-bromomethyl-4-decyloxybiphenyl

反应条件

后处理

1. 1
   其他After completion of the reaction
2. 2
   萃取the resultant mixture was extracted with ether
3. 3
   洗涤washed with water, which
4. 4
   洗涤was further washed with an aqueous solution
5. 5
   workup.ADDITIONcontaining saturated NaHCO3
6. 6
   洗涤washed again with water
7. 7
   浓缩The reaction product was concentrated
8. 8
   其他separated by colomun chromatography

实验过程

To 0.81 g (2.51 mmol) of 4-hydroxymethyl-4'-decyloxybiphenyl was added 15 ml of an aqueous solution containing 47% HBr, and then healed at 115° C. for 3 hours. After completion of the reaction, the resultant mixture was extracted with ether and washed with water, which was further washed with an aqueous solution containing saturated NaHCO3 and washed again with water. The reaction product was concentrated and, then, separated by colomun chromatography, to thereby obtain 0.92 g of 4'-bromomethyl-4-decyloxybiphenyl.

来源