反应 #1519154

ord-e5ec0aa0366549d49afd83bddeed9b01

反应方程式

O=Cc1cc(-c2ccc3c(c2)OCO3)n(S(=O)(=O)c2cccc(Cl)c2)c1
1-(m-Chlorobenzenesulfonyl)2-(3,4methylenedioxyphenyl)-pyrrole-4-carboxaldehyde
CN1CCN(CCCN)CC1
1-(3-aminopropyl)-4-methylpiperazine
CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
NaBH(OAc)3
→
CN1CCN(CCCNCc2cc(-c3ccc4c(c3)OCO4)n(S(=O)(=O)c3cccc(Cl)c3)c2)CC1
1-(m-Chlorobenzenesulfonyl)-2-(3,4-methylenedioxyphenyl)-4-(N-[3-{4-methylpiperazinyl}-propyl]-aminomethyl)-pyrrole

反应物

O=Cc1cc(-c2ccc3c(c2)OCO3)n(S(=O)(=O)c2cccc(Cl)c2)c1
1-(m-Chlorobenzenesulfonyl)2-(3,4methylenedioxyphenyl)-pyrrole-4-carboxaldehyde
CN1CCN(CCCN)CC1
1-(3-aminopropyl)-4-methylpiperazine
CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
NaBH(OAc)3

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他condensed
  2. 2
    其他RT (program 1) 3.26, MS

实验过程

1-(m-Chlorobenzenesulfonyl)2-(3,4methylenedioxyphenyl)-pyrrole-4-carboxaldehyde and 1-(3-aminopropyl)-4-methylpiperazine are condensed and reduced with NaBH(OAc)3 following the procedure of Example 2. HPLC: RT (program 1) 3.26, MS: 531.0.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07612064B2uspto-grants-2009_11