反应 #1519147

反应方程式

tert-butyl piperazine-1-carboxylate

N,N′-dicyclohexylcarbodiimide

1-hydroxybenzotriazole

(2R)-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid

→

expected product

tert-Butyl 4-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl]piperazine-1-carboxylate

溶剂

acetonitrile

反应条件

后处理

1. 1
   过滤The reaction mixture is subsequently filtered
2. 2
   其他the filtrate is then evaporated to dryness
3. 3
   其他The oil thereby obtained
4. 4
   其他is purified by flash chromatography on silica (eluant: toluene/ethyl acetate 80/20)

实验过程

5 g of (2R)-2,3-dihydro-1,4-benzodioxin-2-carboxylic acid (27.8 mmol) are dissolved in 300 ml of acetonitrile. 6 g of N,N′-dicyclohexylcarbodiimide (29.1 mmol) and then 4.1 g of 1-hydroxybenzotriazole (30.6 mmol) are added. Finally, 6.2 g of tert-butyl piperazine-1-carboxylate (33.4 mmol) are added and stirring is carried out for 12 hours at ambient temperature. The reaction mixture is subsequently filtered and the filtrate is then evaporated to dryness. The oil thereby obtained is purified by flash chromatography on silica (eluant: toluene/ethyl acetate 80/20) to yield the expected product in the form of an oil.

来源