反应 #1519144

反应方程式

(1S,2R)-1-aminoindan-2-ol

triethylamine

N,N-bis(2-chloroethyl)-p-toluenesulphonamide

→

expected product

(1S,2R)-1-{4-[(4-Methylphenyl)sulphonyl]piperazin-1-yl}indan-2-ol

溶剂

dimethyl-formamide

反应条件

后处理

1. 1
   其他the dimethylformamide is evaporated off
2. 2
   洗涤washed
3. 3
   其他dried
4. 4
   过滤filtered
5. 5
   其他evaporated
6. 6
   其他The oil obtained
7. 7
   其他is purified by flash chromatography on silica (eluant: dichloromethane/ethyl acetate 95/5)

实验过程

To 8 g of (1S,2R)-1-aminoindan-2-ol (53.6 mmol) dissolved in 80 ml of dimethyl-formamide there are added 15 ml of triethylamine (107.2 mmol) and 15.8 g of N,N-bis(2-chloroethyl)-p-toluenesulphonamide (53.6 mmol). The mixture is heated at 80° C. for 24 hours and then the dimethylformamide is evaporated off. The residue is taken up in dichloromethane, washed, dried, filtered and evaporated. The oil obtained is purified by flash chromatography on silica (eluant: dichloromethane/ethyl acetate 95/5) to yield the expected product in the form of a meringue.

来源