反应 #1519139

反应方程式

tert-butyl piperazine-1-carboxylate

indene oxide

→

tert-butyl trans-4-(2-hydroxy-2,3-dihydro-1H-inden-1-yl)piperazine-1-carboxylate

溶剂

acetonitrile

反应条件

后处理

1. 1
   其他evaporated to dryness
2. 2
   其他The residue obtained
3. 3
   其他is purified by flash chromatography on 1 kg of silica (eluant: dichloromethane/ethanol 95/5)

实验过程

11.6 g of tert-butyl piperazine-1-carboxylate (62 mmol) and 8.2 g of indene oxide (62 mmol) are dissolved in 30 ml of acetonitrile. The reaction mixture is then heated at 60° C. overnight and evaporated to dryness. The residue obtained is purified by flash chromatography on 1 kg of silica (eluant: dichloromethane/ethanol 95/5) to yield tert-butyl trans-4-(2-hydroxy-2,3-dihydro-1H-inden-1-yl)piperazine-1-carboxylate in the form of a white meringue.

来源