反应 #1519136

反应方程式

ammonium hydroxide

3-nitro-2-hydroxyfluorenone

SnCl2

HCl

→

product

收率 65.0%

3-amino-2-hydroxyfluorenone

收率 65.0%

溶剂

acetic acid

反应条件

后处理

1. 1
   萃取After extracting with EtOAc (3×100 ml)
2. 2
   干燥were dried over magnesium sulfate
3. 3
   其他evaporated

实验过程

A mixture of 3-nitro-2-hydroxyfluorenone (1.6 g, 6.6 mmol) and SnCl2 (3 g, 6.6 mmol) was refluxed in 100 ml acetic acid:conc. HCl (1:1) for 1 hour. The mixture was allowed to cool to room temperature and neutralized with ammonium hydroxide. After extracting with EtOAc (3×100 ml), combined organic fractions were dried over magnesium sulfate and evaporated to leave the product as a brown solid (65%) (M+1, 212).

来源