反应 #1519123

ord-b374ca01871c4aa49186c5c35b11b1bf

反应方程式

O=C(Cl)[C@@H]1CCCN1C(=O)C(F)(F)F
(S)-N-(trifluoroacetyl)prolyl chloride
CC(=O)CN
1-amino-propan-2-one
CC(=O)CNC(=O)C1CCCN1C(=O)C(F)(F)F
1-trifluoroacetyl-pyrrolidine-2-carboxylic acid (2-oxo-propyl)-amide

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

A solution of (S)-N-(trifluoroacetyl)prolyl chloride (Aldrich) 1 equiv. in DCM is treated with 1-amino-propan-2-one (1.5 equiv.) in pyridine at rt for 5 hours. After usual work up, it provides 1-trifluoroacetyl-pyrrolidine-2-carboxylic acid (2-oxo-propyl)-amide.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07612059B2uspto-grants-2009_11