反应 #1519120

反应方程式

Z-L-Pro-OH

thionyl chloride

→

Z-L-Pro-Cl

溶剂

DCM

反应条件

后处理

1. 1
   温度is heated
2. 2
   温度to reflux under nitrogen for 20 minutes
3. 3
   浓缩concentrated in vacuo
4. 4
   浓缩concentrated

实验过程

A mixture of Z-L-Pro-OH E-1 (10.0 g, 40.1 mmol, 1 equiv.) and thionyl chloride (30 mL, 401.2 mmol, 10 equiv.) in DCM (200 mL) is heated to reflux under nitrogen for 20 minutes and concentrated in vacuo. The residual oil is coevaporated with toluene 3×, and concentrated to give Z-L-Pro-Cl as an opaque oil.

来源