反应 #1519118

反应方程式

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

p-TSA

→

2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid

溶剂

DCM

2,2-dimethoxypropane

反应条件

后处理

1. 1
   洗涤washed with brine
2. 2
   干燥dried (Na2SO4)
3. 3
   其他purified by silica gel chromatography

实验过程

To a solution of (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4 (300 mg, 1.58 mmol) in 2,2-dimethoxypropane (10 mL) is added p-TSA (20 mg) and the reaction is stirred at rt for 16 hours. The solution is diluted with DCM and washed with brine, dried (Na2SO4) and then purified by silica gel chromatography to afford 1.2 mmol 2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid B-5.

来源