反应 #1519111

反应方程式

Ethyl 2-(Formylaminothiazol-4-yl)-2-oxoacetate

N-Chlorosuccinimide

water

→

title intermediate

Ethyl 2-(2-Formylamino-5-chlorothiazol-4-yl)-2-oxoacetate

溶剂

DMF

反应条件

后处理

1. 1
   过滤The resulting white precipitate was filtered
2. 2
   洗涤washed with water and air
3. 3
   其他dried

实验过程

Ethyl 2-(Formylaminothiazol-4-yl)-2-oxoacetate (9.1 g, 39.87 mmol) (obtained from Aldrich, Milwaukee, Wis.) was slurried in 50 mL of anhydrous DMF. N-Chlorosuccinimide (5.6 g, 41.86 mmol) was added as a solid and the suspension was stirred at room temperature. After 18 hours, the reaction mixture was poured into 500 mL of water. The resulting white precipitate was filtered, washed with water and air dried to afford the title intermediate as a white solid.

来源