反应 #1519107

反应方程式

ammonium chloride

4-chloro-2-cyanopyridine

sodium methoxide

→

2-amidino-4-chloropyridine hydrochloride

溶剂

methanol

反应条件

后处理

1. 1
   温度refluxing
2. 2
   其他The volatile components are then removed in vacuo

实验过程

6.93 g (50 mmol) of 4-chloro-2-cyanopyridine in 40 ml of methanol are treated for one hour with 0.27 g (5 mmol) sodium methoxide. After the addition of 3.00 g (56 mmol) of ammonium chloride, refluxing is carried out for two hours. The volatile components are then removed in vacuo. The 2-amidino-4-chloropyridine hydrochloride so obtained is reacted without further purification.

来源