反应 #1519103

反应方程式

3-(4-chloropyrid-2-yl)-3-oxopropionic acid ethyl ester

2-amidinopyridine hydrochloride

sodium hydroxide

→

6-(4-chloropyrid-2-yl)-2-pyrid-2-yl-pyrimidin-4-ol

溶剂

ethanol

反应条件

后处理

1. 1
   温度refluxing
2. 2
   温度The mixture is cooled
3. 3
   浓缩concentrated to a fifth of its original volume
4. 4
   过滤The crude product is filtered off
5. 5
   其他recrystallised from methanol

实验过程

13.15 g (58 mmol) of 3-(4-chloropyrid-2-yl)-3-oxopropionic acid ethyl ester are dissolved in 400 ml of ethanol, and 9.10 g (58 mmol) of 2-amidinopyridine hydrochloride are added. After the addition of 14.44 ml of 4N sodium hydroxide solution, refluxing is carried out for 7 hours. The mixture is cooled and concentrated to a fifth of its original volume. The crude product is filtered off and recrystallised from methanol, yielding 6-(4-chloropyrid-2-yl)-2-pyrid-2-yl-pyrimidin-4-ol in the form of beige needles.

来源