反应 #1515951

反应方程式

(4-Bromo-2-fluorophenyl)methanamine

ethane sulfonyl chloride

→

N-(4-bromo-2-fluorobenzyl)-ethanesulfonamide

溶剂

pyridine

反应条件

后处理

1. 1
   其他Then, the mixture was quenched with 1N HCl
2. 2
   萃取extracted with ethyl acetate
3. 3
   干燥Drying over magnesium sulfate and evaporation of the ethyl acetate
4. 4
   其他purified by column chromatography

实验过程

(4-Bromo-2-fluorophenyl)methanamine (924 mg, 4.53 mmol) was dissolved in pyridine and ethane sulfonyl chloride (0.82 mL, 8.60 mmol) was added to the solution at 0° C. The mixture was stirred for 1 h at 0° C. Then, the mixture was quenched with 1N HCl and extracted with ethyl acetate. Drying over magnesium sulfate and evaporation of the ethyl acetate and purified by column chromatography gave N-(4-bromo-2-fluorobenzyl)-ethanesulfonamide in pure form (1.06 g, 79%).

来源