反应 #1509673

反应方程式

methyl 2-(2,6-dichloro-9H-purin-9-yl)propanoate

tryptamine

→

title compound

methyl 2-(6-(2-(1H-indol-3-yl)ethylamino)-2-chloro-9H-purin-9-yl)propanoate

溶剂

2-propanol

反应条件

后处理

1. 1
   温度The reaction mixture was cooled to room temperature
2. 2
   浓缩concentrated
3. 3
   其他The residue was purified by silica gel chromatography (10 to 80% ethyl acetate in hexane eluant)

实验过程

A mixture of methyl 2-(2,6-dichloro-9H-purin-9-yl)propanoate (b) (600 mg, 2.2 mmol), tryptamine (420 mg, 2.6 mmol) and 2-propanol (30 mL) was heated at 85° C. in a sealed tube for 16 h. The reaction mixture was cooled to room temperature and concentrated. The residue was purified by silica gel chromatography (10 to 80% ethyl acetate in hexane eluant) to afford the title compound as a white solid. MS m/z 360.1 (M+1).

来源