反应 #1509665

反应方程式

4,6-dichloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidine

( a )

6-chloro-2-iodo-9-isopropyl-9H-purine

tyramine

→

title compound

4-(2-(6-chloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)ethyl)phenol

反应条件

后处理

1. 1
   其他The crude residue was purified by silica gel chromatography (25 to 75% ethyl acetate in hexane eluant)

实验过程

Following the procedure of Example 128b, 4,6-dichloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidine (U.S. Pat. No. 3,399,196) (a) (0.184 g, 0.795 mmol) was reacted with tyramine. The crude residue was purified by silica gel chromatography (25 to 75% ethyl acetate in hexane eluant) to afford the title compound as a solid. MS m/z 332.1 (M+1).

来源