反应 #1509664

反应方程式

4-(2-(2-iodo-9-isopropyl-9H-purin-6-ylamino)ethyl)phenol

5-chloropyridin-3-ylboronic acid

→

title compound

4-(2-(2-(5-chloropyridin-3-yl)-9-isopropyl-9H-purin-6-ylamino)ethyl)phenol

反应条件

后处理

1. 1
   其他The crude product was purified by reverse-phase HPLC(C18 column
2. 2
   洗涤eluting with ACN—H2O 0.05% TFA)

实验过程

Following the procedure of Example 15d, 4-(2-(2-iodo-9-isopropyl-9H-purin-6-ylamino)ethyl)phenol (b) was reacted with 5-chloropyridin-3-ylboronic acid. The crude product was purified by reverse-phase HPLC(C18 column, eluting with ACN—H2O 0.05% TFA) to afford the title compound as an off-white solid.

来源