反应 #1509663

反应方程式

6-chloro-2-iodo-9-isopropyl-9H-purine

tyramine

triethylamine

→

title compound

4-(2-(2-iodo-9-isopropyl-9H-purin-6-ylamino)ethyl)phenol

溶剂

2-propanol

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated
2. 2
   workup.ADDITIONsaturated aqueous sodium bicarbonate solution was added
3. 3
   萃取The mixture was extracted with ethyl acetate (50 ml×3)
4. 4
   干燥The combined organic layers were dried over sodium sulfate
5. 5
   过滤filtered
6. 6
   浓缩concentrated
7. 7
   其他The residue was purified by column chromatography on silica gel (25 to 75% ethyl acetate in hexane eluant)

实验过程

A mixture of 6-chloro-2-iodo-9-isopropyl-9H-purine (a) (1.0 g, 3.1 mmol), tyramine (0.64 g, 4.65 mmol), triethylamine (0.63 g, 6.2 mmol) and 2-propanol (30 mL) was heated at 85° C. for 2 hr. The reaction mixture was concentrated and saturated aqueous sodium bicarbonate solution was added. The mixture was extracted with ethyl acetate (50 ml×3). The combined organic layers were dried over sodium sulfate, filtered, and concentrated. The residue was purified by column chromatography on silica gel (25 to 75% ethyl acetate in hexane eluant) to afford the title compound as a solid. MS m/z 424.1 (M+1).

来源