反应 #1509656

反应方程式

Water

sodium hydride

2,6-dichloro-9H-purine

2-iodopropane

→

title compound

2,6-dichloro-9-isopropyl-9H-purine

溶剂

DMF

反应条件

后处理

1. 1
   workup.STIRRINGthe mixture was stirred at rt for 24 hr
2. 2
   其他the resulting solid precipitate was collected
3. 3
   洗涤washed with water (500 ml) and heptane (2×2.5 L)
4. 4
   其他The crude solid was crystallized from isopropyl acetate (2.1 L)

实验过程

To 2,6-dichloro-9H-purine (a) (998 g, 5.28 mol) dissolved in anhydrous DMF (5.0 L) was added sodium hydride (60% dispersion, 254 g, 6.35 mol) with stirring at 10° C. over 1 hr. 2-iodopropane (1595 g) was added and the mixture was stirred at rt for 24 hr. Water (5.0 L) was added, and the resulting solid precipitate was collected and washed with water (500 ml) and heptane (2×2.5 L). The crude solid was crystallized from isopropyl acetate (2.1 L) to provide the title compound as a solid.

来源