反应 #1509651

反应方程式

2,6-dichloro-9H-purine

sodium hydride

2-iodopropane

→

title compound

2,6-dichloro-9-isopropyl-9H-purine

溶剂

DMF

反应条件

后处理

1. 1
   workup.STIRRINGthe mixture was stirred for 16 hr
2. 2
   浓缩The mixture was concentrated
3. 3
   其他The residue was purified by column chromatography on silica gel
4. 4
   洗涤eluting with hexane/EtOAc (20:1 to 3:1)

实验过程

To 2,6-dichloro-9H-purine (a) (6.0 mmol) dissolved in anhydrous DMF (5.0 mL) was slowly added sodium hydride (7.8 mmol) with stirring at rt over 2 hr. 2-iodopropane was added and the mixture was stirred for 16 hr. The mixture was concentrated. The residue was purified by column chromatography on silica gel, eluting with hexane/EtOAc (20:1 to 3:1) to afford the title compound as a white solid. 1H NMR (500 MHz, CDCl3): δ 8.15 (s, 1H), 4.91 (m, 1H), 1.63 (d, 6H).

来源