反应 #1509637

反应方程式

Compound 10

1-phenyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-benzo[d]imidazole

9-(4-bromophenyl)-9H-carbazole

KF

ethyl acetate

→

Compound 11

收率 47.0%

9-(4′-(1-phenyl-1H-benzo[d]imidazol-2-yl)biphenyl-4-yl)-9H-carbazole

收率 47.0%

溶剂

DMF

反应条件

后处理

1. 1
   温度After cooling to r.t.
2. 2
   过滤The resulting mixture was filtered
3. 3
   其他The solid was collected
4. 4
   workup.DISSOLUTIONdissolved in DCM (200 mL)
5. 5
   过滤which was filtered
6. 6
   浓缩concentrated
7. 7
   其他recrystallized

实验过程

A mixture of Compound 10 (1.41 g, 3.56 mmol), 9-(4-bromophenyl)-9H-carbazole (1.15 g, 3.56 mmol), Pd(dppf)Cl2 (100 mg, 0.14 mmol) and KF (0.619 g, 10.7 mmol) in anhydrous DMF (20 mL) was heated at 120° C. under argon overnight. After cooling to r.t., ethyl acetate (200 mL) was added and the whole was stirred for 15 min. The resulting mixture was filtered. The solid was collected and dissolved in DCM (200 mL), which was filtered, concentrated and recrystallized to give a white solid (Compound 11) (550 mg).

来源