反应 #1509636

反应方程式

triethylamine

4-bromo-benzoyl chloride

N-phenylbenzene-1,2-diamine

→

Compound 8

4-Bromo-N-(2-(phenylamino)phenyl)benzamide

溶剂

dichloromethane

反应条件

后处理

1. 1
   过滤Subsequent filtration

实验过程

To a solution of 4-bromo-benzoyl chloride (11 g, 50 mmol) in anhydrous dichloromethane (DCM) (100 ml), was added N-phenylbenzene-1,2-diamine (10.2 g, 55 mmol), then triethylamine (17 ml, 122 mmol) slowly. The whole mixture was then stirred at room temperature (r.t.) overnight. Subsequent filtration gave a white solid (Compound 8) (6.5 g). The filtrate was worked up with water (300 ml), and then extracted with DCM (300 ml) three times. The resulting organic phase was collected and dried over MgSO4, concentrated and recrystallized in DCM/hexanes to give another portion of white solid (Compound 8) (10.6 g). The total amount of product (Compound 8) was 17.1 g, in 93% yield.

来源