反应 #1509597

反应方程式

dimethylamine

2-Chloro-6-methyl-isonicotinic acid

DIPEA

TBTU

→

title compound

2-Chloro-6,N,N-trimethyl-isonicotinamide

溶剂

water

DMF

反应条件

后处理

1. 1
   萃取extracted with EtOAc
2. 2
   其他The organic layer was separated
3. 3
   其他dried
4. 4
   浓缩concentrated in vacuum

实验过程

To a solution of 2-Chloro-6-methyl-isonicotinic acid (1 g) in DMF (200 ml) at 25° C. was added DIPEA (2.9 mL) and TBTU (1.8 ml). After 5 min, dimethylamine (0.75 g) was added dropwise. This was stirred overnight. The reaction was added to water and extracted with EtOAc. The organic layer was separated, dried and concentrated in vacuum. Flash:chromatography (9:1 to 2:8 gradient cyclohexane:EtOAc) afforded the title compound (320 mg). Rf=0.56 (1:1 cyclohexane:EtOAc)

来源