反应 #1509584

反应方程式

1-Cyclohexyl-3-(3-nitro-benzyl)-urea

DMF

→

title compound

收率 84.1%

1-(3-Amino-benzyl)-3-cyclohexyl-urea

收率 84.1%

溶剂

ethanol

反应条件

后处理

1. 1
   workup.ADDITIONUnder stirring aqueous hydrazine solution (2.5 ml, 80%) was added
2. 2
   过滤filtered
3. 3
   其他The solution was evaporated i.v

实验过程

1-Cyclohexyl-3-(3-nitro-benzyl)-urea (4 g) was suspended in ethanol (70 ml) and Raney nickel (2 g) was added. Under stirring aqueous hydrazine solution (2.5 ml, 80%) was added. DMF was added (50 ml) and the reaction mixture was stirred for additional 2 h and filtered. The solution was evaporated i.v. affording the title compound (3 g, Rf=0.43 DCM/ethanol 19:1).

来源