反应 #1484875

反应方程式

2,8-dichloroquinoline-3-carbaldehyde

phenol

K2CO3

→

8-chloro-2-phenoxyquinoline-3-carbaldehyde

溶剂

DMF

water

反应条件

后处理

1. 1
   萃取extracted with EtOAc (2 times)
2. 2
   洗涤the combined organic layers were washed with water (2 times)
3. 3
   干燥dried over Na2SO4
4. 4
   过滤filtered
5. 5
   浓缩concentrated under reduced pressure
6. 6
   其他The crude product was purified by column chromatography on a Redi-Sep™ column

实验过程

To a solution of 2,8-dichloroquinoline-3-carbaldehyde (1 eq) in DMF (0.25 M) was added phenol (1.5 eq) and K2CO3 (2.0 eq) at rt and the mixture was stirred for 3 h at rt. The mixture was diluted with water, extracted with EtOAc (2 times) and the combined organic layers were washed with water (2 times), dried over Na2SO4, filtered, and concentrated under reduced pressure. The crude product was purified by column chromatography on a Redi-Sep™ column using 0 to 40% gradient of EtOAc in hexane to provide 8-chloro-2-phenoxyquinoline-3-carbaldehyde.

来源