反应 #1483145

ord-5427fbc47308489dab5de2ca73429c34

反应方程式

CC(=O)N[C@H]1[C@H](O[C@H]2[C@H](O)[C@H]3N=C(C)O[C@H]3O[C@@H]2CO)O[C@H](CO)[C@@H](O)[C@@H]1O
chitobiose oxazoline
CC(=O)N[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](NC(C)=O)C(O)O[C@@H]2CO)O[C@H](CO)[C@@H](O)[C@@H]1O
N,N′-diacetylchitobiose
CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H]1O
N-acetyllactosamine
→
C1=NCCO1.CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H]1O
LacNAc oxazoline

反应物

CC(=O)N[C@H]1[C@H](O[C@H]2[C@H](O)[C@H]3N=C(C)O[C@H]3O[C@@H]2CO)O[C@H](CO)[C@@H](O)[C@@H]1O
chitobiose oxazoline
CC(=O)N[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](NC(C)=O)C(O)O[C@@H]2CO)O[C@H](CO)[C@@H](O)[C@@H]1O
N,N′-diacetylchitobiose
CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H]1O
N-acetyllactosamine
—
trisaccharide oxazoline

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

To prepare trisaccharide oxazoline 3, the 4′,6′-O-benzylidene group in 15 was selectively removed by treatment with 80% aqueous AcOH at 50 C. The resulting compound 21 was then selectively glycosylated at the 6′-OH position with 2,3,4,6-tetra-O-benzoyl-β-D-mannopyranosyl trichloroacetimidate under the catalysis of TMSOTf to give trisaccharide derivative 23 (76%). De-O-benzoylation of 23 with subsequent O-acetylation afforded the O-acetylated pentenyl glycoside 25. Finally, compound 25 was converted to the oxazoline derivative by treatment with NIS/TESOTf to give 26, which was de-O-acetylated to provide trisaccharide oxazoline 3. On the other hand, the known chitobiose oxazoline 6[15] and the LacNAc-oxazoline 7[16] were prepared from O-acetylated N,N′-diacetylchitobiose and N-acetyllactosamine, respectively, following the reported procedure.[15, 16]

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08900826B2uspto-grants-2014_12