反应 #1483110

反应方程式

Octreotide pamoate

→

Pamoic Acid

溶剂

EtOAc

benzyl alcohol

—

in-water

反应条件

后处理

1. 1
   workup.ADDITIONadded to the polymer solution
2. 2
   其他yielding a homogeneous organic phase
3. 3
   其他to provide an emulsion
4. 4
   其他The emulsion was collected directly into a 0.3% PVA solvent extraction solution (150 mL)
5. 5
   萃取to extract EtOAc
6. 6
   过滤Hardened microparticles were collected by filtration
7. 7
   洗涤washed with water, air
8. 8
   其他dried
9. 9
   其他stored at 4° C.

实验过程

Microparticle formulations (Table 5, Q-W) were prepared by an oil-in-water emulsion/solvent extraction method. PLGA polymer (MW 24,000, 180 mg) was dissolved in EtOAc (1000 μL). Octreotide pamoate (20 or 40 mg) was dissolved in benzyl alcohol (BnOH, 1000 μL) and added to the polymer solution yielding a homogeneous organic phase. The resulting organic phase was combined with a 1% PVA aqueous phase in a ratio of 1:2 to provide an emulsion. The emulsion was collected directly into a 0.3% PVA solvent extraction solution (150 mL) and stirred for four hours to extract EtOAc. Hardened microparticles were collected by filtration, washed with water, air dried and stored at 4° C.

来源