反应 #1470462

反应方程式

potassium carbonate

6Z-16-bromohexadec-6-enoic acid

→

Z-oxacycloheptadec-7-en-2-one

收率 53.0%

溶剂

N-methyl- pyrrolidone

N-methyl pyrrolidone

反应条件

后处理

1. 1
   其他After usual work up 18 g of crude product were obtained

实验过程

25 g of potassium carbonate were suspended in 300 ml of N-methyl pyrrolidone. 30 g (0.09 mol) of crude 6Z-16-bromohexadec-6-enoic acid in 200 ml of N-methyl- pyrrolidone were added dropwise while stirring at 110-115° C. within 10 hours. After usual work up 18 g of crude product were obtained, and after chromatography 12 g (53%) of Z-oxacycloheptadec-7-en-2-one were obtained having the following characteristics: Z/E=93/7;

来源