反应 #1470459

反应方程式

Z-8-methyloxacyclopentadec-7-en-2-one

methanol

→

8-methyloxacyclopentadecan-1-one

收率 83.0%

反应条件

后处理

1. 1
   其他hydrogenated (1.5 hours)
2. 2
   过滤Then, the mixture was filtered over Celite
3. 3
   浓缩the solution was concentrated
4. 4
   workup.DISTILLATIONdistilled in a bulb-tube
5. 5
   其他chromatographed

实验过程

25 g (0.10 mol) of Z-8-methyloxacyclopentadec-7-en-2-one were dissolved in 150 ml of methanol and hydrogenated (1.5 hours) with 2 g of 5% palladium-on-carbon with 100 mbar over-pressure. Then, the mixture was filtered over Celite, and the solution was concentrated, distilled in a bulb-tube and chromatographed. There were obtained 20 g (83%) of 8-methyloxacyclopentadecan-1-one were obtained having the following characteristics:

来源