反应 #1470457

反应方程式

(5-carboxypentyl)triphenylphosphonium bromide

9-hydroxy2-nonanone

→

14-hydroxy-7-methyltetradec-6-enoic acid

收率 111.2%

溶剂

tetrahydrofuran

tetrahydrofuran

反应条件

实验过程

45.7 g (0.1 mol) of (5-carboxypentyl)triphenylphosphonium bromide were placed in 200 ml of tetrahydrofuran and 25 g (0.22 ol) of potassium t-butylate in 100 l of tetrahydrofuran were added dropwise at 0° C. Then, 15.8 g (0.1 mol) of 9-hydroxy2-nonanone were added. After stirring for 30 minutes and usual work up, 28.5 g of crude 14-hydroxy-7-methyltetradec-6-enoic acid were obtained.

来源