反应 #1470454

反应方程式

(7-carboxyheptyl)triphenylphosphonium bromide

8-bromooctanal

→

8Z-16-bromohexadec-8-enoic acid

溶剂

tetrahydrofuran

tetrahydrofuran

反应条件

后处理

1. 1
   workup.ADDITIONwere added dropwise

实验过程

48.5 g (0.1 mol) of (7-carboxyheptyl)triphenylphosphonium bromide were suspended in 150 ml of tetrahydrofuran. After the addition of 24.7 g (0.22 mol) of potassium t-butylate in 50 ml of tetrahydrofuran 26.4 g (0.12 mol) of 8-bromooctanal were added dropwise. After the usual work up 35.4 g of crude 8Z-16-bromohexadec-8-enoic acid were obtained having the following characteristics: Z/E=93/6;

来源